Terms & Properties

Preferred Name:  Cocaine

Definition:  A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.

Label:  Cocaine

NCI Thesaurus Code:  C80153 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  C0009170  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl Benzoate

Cocaine

COCAINE

External Source Codes: 

CAS Registry Number	50-36-2 (see NLM ChemIDplus info)
FDA UNII Code	I5Y540LHVR
ChEBI ID	CHEBI:27958 (see ChEBI info)
UMLS CUI	C0009170

Other Properties:

Name	Value (qualifiers indented underneath)
Chemical_Formula	C17H21NO4
code	C80153
Contributing_Source	FDA
Legacy Concept Name	Cocaine
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit-stage.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C80153